Pakistan suffered a significant setback on Sunday when pace bowler Hasan Ali and all-rounder Faheem Ashraf were ruled out of the first Test against Australia through injuries.
Hasan has a muscle strain and Faheem an injured hamstring and will miss the Test starting in Rawalpindi from Friday.
The Pakistan Cricket Board (PCB) said spinning all-rounder Iftikhar Ahmed and fast bowler Mohammad Wasim Junior will replace the injured duo.
“Both Iftikhar and Wasim (chosen due to their all-round ability) will reach Islamabad tonight and start their three-day isolation at the team hotel,” said a PCB release. The pair will join the rest of the squad after clearing Covid-19 tests.
Hasan, 27, has been anchoring Pakistan's bowling attack along with Shaheen Shah Afridi in the last 12 months.
He took a ten-wicket haul in the last Test in Rawalpindi, against South Africa in February, before taking nine wickets in Harare against Zimbabwe two months later. He finished the year with 41 wickets in eight Tests, just behind India's Ravi Ashwin (54) and Shaheen (47).
Faheem has been a star with both bat and ball, allowing Pakistan to use two spinners in matches.
"Faheem and Hasan will rejoin the squad in the coming week and after completing their three-day mandatory isolation integrate with the rest of the squad during the first Test. Both are expected to regain full fitness before the second Test that will be played in Karachi 12-16 March," the PCB said.
The third and final Test is in Lahore from March 21. Australia will also play three one-day internationals and a T20I on the tour.
Pakistan's revised squad for first Test: Babar Azam (captain), Mohammad Rizwan, Abdullah Shafique, Azhar Ali, Fawad Alam, Haris Rauf, Iftikhar Ahmed, Imamul Haq, Mohammad Wasim Junior, Nauman Ali, Sajid Khan, Saud Shakeel, Shaheen Shah Afridi, Shan Masood, Zahid Mahmood.