PARIS: Tens of millions of people across the world are thought to suffer from long Covid, but four years after the pandemic was declared, this elusive condition still cannot be tested for — let alone treated.

However research could be finally starting to find early clues on the trail of long Covid, raising hopes of future breakthroughs that may also illuminate other stubbornly ambiguous chronic syndromes.

Long Covid is the name given to a wide variety of symptoms still being suffered by people weeks and months after they first contracted the SARS-CoV-2 virus.

The most common are fatigue, shortness of breath, muscle pain and brain fog.

One notable study released last month showed there were significant differences in the proteins of the blood of more than 110 long Covid patients.

Onur Boyman, a Swiss researcher and senior author of the Science study, said he believes this is a “central puzzle piece” in what keeps Covid raging for so long in the bodies of some people.

Part of the body’s immune system called the complement system, which normally fights off infection by killing infected cells, remains active in people with long Covid, continuing to attack healthy targets and causing tissue damage, the researchers said. Boyman said that when people recovered from long Covid, their complement system also improved, suggesting a strong link between the two.

“It shows that long Covid is a disease and you can actually measure it,” Boyman said, adding the team hopes this could lead to a future test.

Researchers not involved in the study cautioned that this complement system “dysregulation” could not explain all the different ways that long Covid seems to attack patients.

Still, it is “great to see papers coming out now showing signals which might start to explain long Covid”, said Claire Steves, professor of ageing and health at King’s College London.

‘Every aspect of my life’

Lucia, a US-based long Covid sufferer who preferred not to give her last name, said that “studies like these bring us a lot closer to understanding” the condition.

She pointed to another recent paper which found damage and fewer mitochondria in the muscles of long Covid patients, which could indicate why many patients become exhausted after even a small amount of exercise.

For Lucia, long Covid turned climbing up the stairs to her apartment into a daily battle.

When she first caught Covid in March 2020, Lucia said she could not have imagined how the condition would “affect every aspect of my life — including socially and financially”.

Lucia, a member of the Patient-Led Research Collaborative, emphasised that people with long Covid do not only have to deal with their many health issues. They also have “to contend with disbelief or dismissal from the medical community or from within their social circles”, she said.

The importance of supporting patients was highlighted by a BMJ study this week, which found that group rehab improved the quality of life of long Covid patients.

Why has it been so hard?

Ziyad Al-Aly, a clinical epidemiologist at Washington University in St Louis, said long Covid has been so elusive because it is a “multi-system disease”.

Published in Dawn, February 11th, 2024

Opinion

Editorial

IHK resolution
Updated 08 Nov, 2024

IHK resolution

If the BJP administration were to listen to Kashmiris, it could pave the way for the resumption of the political process in IHK.
Climate realities
08 Nov, 2024

Climate realities

THE Air Quality Index in Lahore once again shot past the 1,000-level mark on Wednesday morning, registering at an...
Rule by fear
08 Nov, 2024

Rule by fear

THE abduction of an opposition MNA, as claimed by PTI, is yet another grim episode in Pakistan’s ongoing crisis of...
Trump 2.0
Updated 07 Nov, 2024

Trump 2.0

It remains to be seen how his promises to bring ‘peace’ to Middle East reconcile with his blatantly pro-Israel bias.
Fait accompli
07 Nov, 2024

Fait accompli

A SLEW of secretively conceived and hastily enacted legislation has achieved its intended result: the powers of the...
IPP contracts
07 Nov, 2024

IPP contracts

THE government expects the ongoing ‘negotiations’ with power producers aimed at revising the terms of sovereign...